Reliability of Holter registration in ischemic heart disease

Introduction We studied the reliability of a new ST-segment analysis on a 24-hour 12-lead holter recording comparing ST-depression during exercise testing with active molsidomine and placebo drugs in a randomized, double-blind, crossover, clinical trial. Methods and results 35 patients with proven coronary heart disease received either 4 mg regular molsidomine, 8 mg molsidomine SR (Sustained Release) or placebo tablets. Exercise tests were performed at 3 and 12 hours after drug intake. Myocardial ischemia was measured using conventional cyclo-ergometry (onset of ST-depression during exercise test on cycloergometer E.C.G.) and 24 h holter monitoring (Mortara H12) also during the exercise tests.